On January 11th, 2022, the trailer for Nickelodeon’s Big Nate, an animated Paramount+ series (based on the series of books by the same name) about a rebellious sixth-grader named Nate, was released (shown below). At the 1:20 mark, Big Nate’s teacher tells him not to drop a beaker of liquid. He drops it in defiance, causing gas to fill the screen.
On January 15th, YouTuber RedHairMan posted an edit of the scene where Nate drops the beaker and there’s an explosion, gaining over 31,000 views in two weeks (shown below). This is one of the earliest memes to use the footage.